Summary

Low physical fitness, physical inactivity, excess adiposity and other cardiovascular risk factors are closely linked to numerous chronic diseases, including several types of cancer. Since many tumors may have a metabolic origin, it is essential to understand how fitness, physical activity, adiposity and other cardiovascular risk factors are related to cancer incidence and mortality.

In this context, the PreCaFit project, funded by the European Union, aims to analyze these associations in large epidemiological cohorts. It will also explore how physical exercise may influence various biomarkers related to cancer development. To achieve this, objective measurements and data from extensive population-based databases will be used.

The project’s findings will provide key scientific evidence for the design of more effective and safer prevention strategies and will help identify lifestyle-related behaviors that could reduce the risk of cancer.

Status

Current status: Preparation of publications.

Funding

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska Curie grant agreement No 101028929.

Selected Publications

• Cadenas-Sanchez C, Sanchez-Lastra MA, Tarp J, Ekelund U, Dalene KE. Occupational physical activity and incidence and mortality of 14 cancers in 404,249 adults. Nature Communications (Accepted).
• Katsaroli I, Sidossis L, Katsagoni C, Sui X, Cadenas-Sanchez C, Myers J, Faselis C, Murphy R, Samuel IBH, Kokkinos P. The Association between Cardiorespiratory Fitness and the Risk of Breast Cancer in Women. Med Sci Sports Exerc. 2024 Jun 1;56(6):1134-1139. doi: 10.1249/MSS.0000000000003385. Epub 2024 Jan 10.

The study in the media

https://www.ideal.es/miugr/universidad-andaluza-proyectos-20210302103652-nt.html