Time-restricted eating and supervised exercise for improving hepatic steatosis and cardiometabolic health in adults with obesity: the TEMPUS randomised controlled trial
Summary Background and aims: Metabolic dysfunction- associated steatotic liver disease is a major public health problem considering its high prevalence and its strong association with extrahepatic diseases. Implementing strategies based on an intermittent fasting approach and supervised exercise may mitigate the
Development and validation of a novel virtual reality software for improving disability and quality of life in patients with stroke
Summary What is the problem to be addressed? Stroke represents a leading cause of global disability and the estimated annual cost for new stroke cases in Spain is 1989 millions €. The number of stroke survivors is increasing annually representing a heavy
Efficacy of different feeding schedules with 8-hour intake restriction on visceral adipose tissue and cardiometabolic health
Summary Abstract Background and aims: To investigate the efficacy and feasibility of three different 8 h time-restricted eating (TRE) schedules (i.e., early, late, and self-selected) compared to each other and to a usual-care (UC) intervention on visceral adipose tissue (VAT) and
Diurnal variation in the effect of exercise on metabolic health
Summary Abstract Background and aims: Mammalian cells possess molecular clocks which adequate functioning is decisive for metabolic health. Exercise is known to modulate these clocks, potentially having distinct effects on metabolism depending on the time of day. Specific aims of this
Adaptations of human brown adipose tissue to overnutrition
Summary Brown adipose tissue (BAT), also referred to as brown fat, exhibits high thermogenic capacity, aiding mammals in maintaining body temperature. Preclinical investigations have highlighted BAT's pivotal role in adapting to high-fat diets and excessive caloric intake, thus mitigating the risk
Activating brown adipose tissue through exercise in young adults: A Randomized controlled trial
Summary The energy expenditure capacity of brown adipose tissue (BAT) makes it an attractive target as a therapy against obesity and type 2 diabetes. BAT activators namely catecholamines, natriuretic peptides and certain myokines, are secreted in response to exercise. ACTIBATE will determine
Effect of a protein-enriched drink on muscle function recovery and markers of muscle damale after a single bout of exercise at high-intensity
Summary The quantity and quality of the diet plays a key role in sport perfomance. A single high intensity exercise bout with may induce muscle damage and may impair muscle function. Ingestion of protein-enriched drink may stimulate muscle protein sinthesis. The
Exercise in the prevention and treatment of obesity and insulin resistance: Smart analysis-smart interventions. SmarterMove
Summary Obesity and type 2 diabetes are major public health problems. Despite much has been advanced in the knowledge about these two pathologies, new approaches need to be identified and implemented to reach sufficient knowledge and strategies to successfully fight against
