TEIDe Tailored Exercise Interventions for Dementia Prevention: Bridging Research Evidence and Primary Care Practice

IP: Irene Esteban-Cornejo

Contacto: ireneesteban@ugr.es teide.nutribrain@gmail.com

Summary

The primary aim of the TEIDe Project is to identify individuals at high risk of dementia and to enhance understanding of the interplay between exercise and cognitive aging. To achieve this, the TEIDe consortium will establish an integrated framework combining predictive, precision, mechanistic, and clinical application approaches for the effective prevention of dementia. The four main project research questions focus on:
(i) the discriminative power of dementia risk scores;
(ii) the optimal types and doses of exercise that confer cognitive benefits based on individual patient characteristics;
(iii) the underlying mechanisms of the effect of exercise on cognition; and
(iv) the feasibility of implementing a holistic approach in primary healthcare settings.

To address these research questions, data are leveraged from existing cohort studies, including over 3 million individuals, and from seven completed, rigorously conducted exercise-based randomized controlled trials (RCTs) in middle-aged and older adults with a range of cognitive functions. With nine partners from eight countries (i.e., Spain, Norway, Germany, Italy, Slovakia, Romania, the USA, and Canada), the consortium integrates academia, healthcare, enterprise, and operational stakeholders. This project will generate at least four products that can be implemented in healthcare systems in the relatively short term: (i) dementia risk scores, (ii) exercise prescription algorithms, (iii) user-friendly exercise manuals, and (iv) modifiable risk factors for non-pharmaceutical treatment.

The deliverables will benefit patients and clinicians, contributing to the prevention of cognitive decline and early-stage Alzheimer´s disease, promoting personalized medicine in dementia care. The TEIDe project stands as a collaborative effort to advance world-class research and strengthen research links, paving the way for improved prediction of treatment benefits and personalized interventions.

Consortium structure:

Coordinator:

Irene ESTEBAN-CORNEJO, Granada Biosanitary Research Institute (iBS.Granada), and University of Granada, Granada, Spain

Partners:

Elisabeth WENGER, HMU Health and Medical University Potsdam, Germany
Mario POSSENTI, Alzheimer Italy Federation, Italy
Dorthe STENSVOLD, Norwegian University of Science and Technology, Norway
Oliviu MATEI, HOLISUN SRL, Romania
Barbara UKROPCOVA, Slovak Academy of Sciences, Slovakia
Juan Ángel BELLÓN SAAMEÑO, Andalusian Public Foundation for Biomedical and Health Research in Malaga – Biomedical Research Institute of Malaga and Nanomedicine Platform, Spain

Collaborators: